منابع مشابه
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD(+) leve...
متن کاملMitochondrial Sirtuin 3 and Renal Diseases.
Mitochondria are dynamic organelles whose functions are tightly regulated at multiple levels to maintain proper cellular homeostasis. Mitochondrial Sirtuin 3 (SIRT3), which belongs to an evolutionary conserved family of NAD+-dependent deacetylases, is a key regulator of the mitochondrial respiratory chain, ATP production, and fatty acid β-oxidation, and it exerts an antioxidant activity. Change...
متن کاملSirtuin 3 in acute kidney injury
Twenty years of research and advances in pathophysiology have not yet translated into effective therapeutic tools for improving survival after an acute kidney injury (AKI) episode. AKI is a disease process characterised by rapidly decreasing renal excretory function, with accumulation of nitrogen metabolism and other waste products. AKI is a major public health concern with a rapidly increasing...
متن کاملChanges in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.
OBJECTIVE Sirtuins (SIRTs) play a prominent role in metabolism, apoptosis, aging, inflammation, and epigenetics. Inflammation, apoptosis, and epigenetics are pathogenic issues in rheumatoid arthritis (RA). This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA. MATERIAL AND METHODS Fifty-four patients with RA and 26 healthy controls were enrolled. Disease activity w...
متن کاملImplementation of "Chronic Care Model" for Diabetes Care in Iranian Primary Health Care: Does it work?
Objective: Traditional health care systems were not capable to face successfully with chronic diseases including diabetes mellitus. In this regard, the Chronic Care Model or CCM was created to promote quality of care. The aim of this study was to examine whether establishment of chronic care model, with focus on diabetic patients, has led to clinically significant outcomes in Iran. Materials a...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2016
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(16)30411-6